Cell Membrane and Ion Channels
نویسندگان
چکیده
Contents 1. Introduction 2. Experimental techniques 2.1. Ion concentrations 2.2. Whole-cell recording 2.3. Current clamp and voltage clamp 2.4. Voltage clamp experiments 2.5. Recording single channel activity 2.6. Rundown 2.7. Effect of intracellular calcium buffering 2.8. Heterogeneity of cardiac cells 2.9. Electrical pathway between cells 3. Modeling the cell membrane and ion channels 3.1. Electrical equivalent model of the cell membrane 3.2. Hodgkin and Huxley model 3.3. Ion channel gating 3.4. Single channel kinetics 3.5. Deterministic, stochastic and Markov models of ion channel gating 4. A stochastic model of the cell membrane 4.1. Stochastic interpretation of rate constants 4.2. From deterministic to stochastic model 4.3. Open and closed times of a single channel 4.4. Stochastic behavior of the membrane conductance 5.
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